2022 AAN Annual Meeting

Impel presented four scientific abstracts as part of the 2022 American Academy of Neurology Annual Meeting, including data from our pivotal Phase 3 STOP-301 trial of Trudhesa® for the acute treatment of migraine.

2022 HCOP Winter Conference

Impel attended the 2022 Headache Cooperative of the Pacific’s 14th Annual Winter Conference, held January 28-29 to support communication among headache providers and researchers. This two-day, educational and informative event provides the necessary tools and best practices to better diagnose and treat headache patients.

Nasal Delivery of Acute Medications for Migraine: The Upper Versus Lower Nasal Space

Vincent Martin, John Hoekman, Sheena K. Aurora and Stephen B. Shrewsbury

Full manuscript can be accessed here:

Abstract: The acute treatment of migraine requires effective drugs that are well tolerated and provide
rapid and consistent pain relief. Oral tablets are the most commonly used acute treatment for
migraine; however, their effectiveness is limited by the rate of gastrointestinal (GI) tract absorption
and first-pass hepatic metabolism, and they may not be ideal for patients experiencing GI motility
issues. Nasal delivery is an attractive alternative route as it may circumvent GI tract absorption,
avoid first-pass metabolism in the liver, and potentially reduce the frequency of GI adverse events.
The large surface area and high vascularity within the nose may permit rapid absorption of therapeutics
into the systemic circulation, allowing for rapid onset of action. However, the site of drug
deposition (upper versus lower nasal cavity) may influence drug pharmacokinetics. Most approved
nasal migraine therapies target the lower nasal space where the epithelium is less permeable, and
they may be quickly cleared away due to increased ciliary function or dripping from the nose or
swallowing, resulting in variable absorption and limited bioavailability. Together with its abundant
vascularization, relative mucosal thickness stability, and low clearance rates, the upper nasal space
harnesses the benefits of nasal delivery to potentially maximize drug efficacy.

To cite: Martin, V.; Hoekman, J.; Aurora, S.K.; Shrewsbury, S.B. Nasal Delivery of Acute Medications for Migraine: The Upper Versus Lower Nasal Space. J. Clin. Med. 2021, 10, 2468. https://doi.org/10.3390/jcm10112468